Author Archive
FY 2011 degree ceremony
March 23, 2012, commencement ceremony FY 2011 Nagoya City University is carried out, were enrolled in our laboratory (field of regenerative medicine), Mr. Akira Hong summer (medical and crisis management anesthesia), you Masato Sawada, you Eisuke Kako ( fields) Pathology clinical pathology) forensic field (medicine was to obtain a master's degree (), you Morinaga Dr. Tomoya. You Sawada Best Paper Award Graduate School of Medicine, you Kako was awarded the Best Paper Award the same. I wish you more and more of us working you.
New cell structure is applied to the nerve cells where dead
Graduate student from the same research group and Masato Sawada (regenerative medicine), the nerve in the brain Professor Sawamoto sum total of the University Graduate School of Medicine about the announcement of research results on the mechanism of regeneration of nerve cells in the brain by the Nagoya City University press release was to elucidate the mechanism of cell renewal are interchanged. This achievement, (August 10, U.S. Eastern time) will be published in the Journal of Neuroscience scientific journal of the United States.
In recent years, stem cells also exist in the adult brain, new nerve cells are made that has been found. However, it has been replaced by the new nerve cells and how the nerve cells by the disease dies out of date or was unknown. In the present study, by using a special microscope, continue to observe a long period of time the nerve cells in the brain of live animals, and that there is a mechanism where new nerve cells is applied to the nerve cell dies, this mechanism that is regulated by the activity of the brain has been elucidated for the first time.
This mechanism may help in the development of regenerative medicine by a method of treating brain diseases, for example.
This study was carried out as joint research, etc. (Division of Biological constant functional development mechanism) participated in the University and National Institute for Physiological Sciences.
<More information on the contents>
Recent studies that background, the presence of the adult brain stem cells also have to play the nerve cells had become apparent. Previous studies in a way, because it was to analyze the postmortem brain, nerve cell turnover in the brain how, or from being played was unknown. In addition, the relationship between brain activity and nerve cell regeneration, it was not poorly understood. We are using the technology for a long period of time to observe nerve cells in live animals, was studied in detail the relationship between brain activity and the mechanism of this nerve cell regeneration.
At a site called the olfactory bulb of odor information processing in the brain involved in the research methods, the nerve cells to play actively are known to have. We use a special microscope by Prof. Junichi Nabekura collaboration with the National Institute for Physiological Sciences, can be observed in the brain nerve cells alive called "two-photon microscopy", this time two nerve cells of the olfactory bulb observed repeatedly over the months went on. As a result, we succeeded in capturing the state dies, the old nerve cells, nerve cells involved in the neuronal circuits or new. Also, kill the nerve cells targeted with a laser, we found that new nerve cells will be played in the same location. In addition, shut down the odor information to insert the plug into the nose of the mouse, and extinguish the stimulus to the brain, was found to be of nerve cell regeneration will not occur in the same place.
Mechanism is applied to the location of new nerve cells nerve cells in the brain dead conclusion exists and how it works is that it is regulated by the activity of the brain has been elucidated for the first time.
By previous studies of our potential for medical applications, new nerve cells are produced from stem cells in the brain, when you kill nerve cells in many diseases such as cerebral infarction, moved to the area, nerve to play the part of the cell has been found. However, because of its regeneration efficiency is low, the function of the brain is not fully recovered. If you can increase the regeneration efficiency of nerve cells was lost by applying the mechanism was revealed this time, it may be helpful in the treatment of brain disease. In addition, to elucidate the mechanism by the addition of new nerve cells in brain activity, there is improvement of the Rehabilitation Act and after the injury, could contribute to cell and regenerative medicine using iPS.
<Details of the paper will be published>
Posted: Journal of Neuroscience, Volume 31 ,11587 -11596 title page: Sensory input regulates spatial and subtype-specific patterns of neuronal turnover in the adult olfactory bulb
Author: (Nagoya City) Masato Sawada (National Institute for Physiological Sciences), Akira 氣弘 sum (Nagoya City) Naoko Kaneko, Hiroyuki Inada (National Institute for Physiological Sciences), (Nagoya City) Yasuko Kato, husband right one thousand Yanagawa (Gunma Univ.) (College of Medicine, Fukushima), Kazuto Kobayashi (Hokkaido University) Tomomi Nemoto, Junichi Nabekura (National Institute for Physiological Sciences), the sum total Sawamoto (Nagoya City)
Heisei 24 fiscal year graduate student recruitment of candidates
We are currently looking for a (master's degree, doctoral) graduate students to participate in the study from April 2012.
If you are interested, please feel free to e-mail to contact (sawamoto@med.nagoya-cu.ac.jp Sawamoto total sum).
In our laboratory, we study molecular and cellular biology and mechanism of generation and regeneration of the brain, the study of medicine to help them.
Have been used by various techniques (mouse, zebrafish monkey) cells, molecules and individual level.
Has been structured diverse members, including those from the Faculty of Agriculture, science and medicine, pharmaceutical science and engineering.
Of neuron-glial brain disease model of ischemia-related neurogenesis and olfactory mechanism of generation of liquid flow and ciliary movement of the ventricular wall, move-cell neurogenesis in the adult subventricular zone, current research depression and hippocampal neurogenesis in the development of a method for inducing interferon therapy elucidating the mechanism of reproduction and regeneration (for information such as the question of the relationship and past admissions schedule has been posted on the website of the university.)
Recruiting an auxiliary in-experiment (End)
Recruitment of assistants The experiment was terminated.
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Recruitment will be an experiment in-aid.
In the field of regenerative medicine Nagoya City University Graduate School of Medicine is conducting various studies of the molecular and cellular level, individuals that aims to play a neuron in the brain after injury. To recruit someone else to take this time to the aid of experiment, using mice.
Job Description: Analysis of mouse brain tissue, reproductive management of genetically modified mice, such as genotyping. Please contact us for details.
It depends on the provisions of the Nagoya City University / part-time: treatment.
460 yen per day: 1027-1380 yen hourly rate travel allowance: holiday: Negotiable Salary: Sat, Sun, holiday and New Year there, paid leave (including 1 hour break) 9:00 to 17:00 Working hours: health insurance, welfare pension insurance, workers' compensation, employment insurance work location: Nagoya City University Graduate School of Medicine regenerative medicine sector insurance provision to limit
URL: http://k-sawamoto.com/
Application period: May 31, 2011 (Tuesday).
As soon as the right person has decided to exit the recruiting.
Content screening: After the document screening, do the interview.
Appointed time: as soon as possible after the decision adopted (Negotiable).
Qualifications: university of science, junior college, vocational school graduates, who do not allergic to animals.
Also will teach you how inexperienced.
How to apply: to the following, please send (can e-mail) your resume. Also accepts inquiries by e-mail.
1 Kawasumi, Mizuho-ku, Nagoya, Mizuho-cho character 〒 467-860 [Contact]
Naoko Kaneko naokoka@med.nagoya-cu.ac.jp field of regenerative medicine Nagoya City University Graduate School of Medicine
Tel (052) 853-8532
(Posted to the journal Neuron) mechanism to move while forming a tunnel in astrocytes neurogenesis
Featured Article
New Neurons Clear the Path of Astrocytic Processes for Their Rapid Migration in the Adult Brain.
Kaneko N, Marín O, Koike M, Hirota Y, Uchiyama Y, Wu JY, Lu Q, Tessier-Lavigne M, Alvarez-Buylla A, Okano H, Rubenstein JL, Sawamoto K.
FULL TEXT Neuron 2010 Jul 29;. 67 (2) :213-223.
PREVIEW in Neuron: Going Tubular in the Rostral Migratory Stream: Neurons [...]
New treatise on the movement of neurons along the blood vessel regeneration in ischemic stroke model
Subventricular Zone-Derived Neural Progenitor Cells Migrate Along a Blood Vessel Scaffold Toward the Post-Stroke Striatum
Kojima T, Hirota Y, Ema M, Takahashi S, Miyoshi I, Okano H, Sawamoto K.
The subventricular zone (SVZ) of the adult brain contains neural stem cells that have the capacity to regenerate new neurons after various insults. Brain ischemia causes damage [...]
New review paper End recruitment researcher
Researcher recruitment has ended.
In addition, persons who are considered to be admitted to participate in our laboratory (MSc & PhD) University of Tokyo Graduate School of Medicine from fiscal 2010, (sawamoto@med.nagoya-cu.ac Sawamoto in advance. Please contact jp).
If you would like to know about admissions, please visit the University Graduate School of Medicine.
[Researcher recruitment was terminated;
Following recruitment has ended.
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In our laboratory, we are seeking the following personnel present.
The recruiting a postdoctoral research focuses on the relationship of depressive symptoms and functional changes of neural stem cells and progenitor cells present in the subventricular zone in the adult brain, the hippocampus a name) a postdoctoral fellow. As the contents of the experiment, cell culture experiments using primary cultures of mouse brain histological analysis will be the principal.
Appointed time having a doctoral degree: qualification - June 2009 (minor changes are possible.)
Until March 2011 term of office. There is possibility of extension by the results a few years.
Please send the following e-mail to contact (more than one name) Contact Inquirer (free style) resume performance list (with photos) How to apply:.
We will have an interview for the candidate immediately after the deadline last April 28, to be determined within 2 weeks deadline.
(Naokoka@med.nagoya-cu.ac.jp) regenerative medicine field Naoko Kaneko, Nagoya City University Graduate School of Medicine Contact:
Cover illustration
(Red) to mature and go to the olfactory bulb neurons (blue) to produce neural stem cells of the subventricular zone production of neurons in the adult mouse subventricular zone: The cover illustration.
Kaneko, N and Sawamoto, K. (2009)
Adult neurogenesis and its alteration under pathological conditions
.. Neurosci Res 63:. 155-164 (REVIEW ARTICLE)
You can participate in the study as a graduate student of MSc-PhD [. ;
As the theme of the dissertation, there are challenges, for example, as follows.
Liquid flow generation mechanism of ciliary movement by the ventricle ependymal cell maturation and analysis of adult olfactory bulb neurons control mechanism of production by sensory input, analysis and transfer mechanisms neurogenesis in the subventricular zone of adult primates, rodents development inquiries and treatment mechanisms of nerve regeneration in ischemic disease models, mechanisms of neurogenesis using genetic techniques for elucidation of the significance, and zebrafish: up to sawamoto@med.nagoya-cu.ac.jp . You can also visit the laboratory.
