1. Sunabori, T., Tokunaga, A., Nagai, T., Sawamoto, K., Okabe, M., Miyawaki, A., Matsuzaki, Y., Miyata, T., and Okano, H*. (2008)
Stage/Cell cycle phase specific nestin gene expression coordinated with the morphological alteration of embryonic cortical neural progenitor cells.
J. Cell Sci. In Press
2. Hirota, Y., Ohshima, T., Kaneko, N., Ikeda, M., Iwasato, T., Kulkarni, A., Mikoshiba, K., Okano, H., and Sawamoto, K*. (2007)
Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone.
J. Neurosci. 27, 12829-12838.
3. Adachi, K., Mirzadeh, Z., Sakaguchi, M., Yamashita, T., Nikolcheva, T., Gotoh, Y., Peltz, G., Gong, L., Kawase, T., Alvarez-Buylla, A., Okano, H.*, and Sawamoto, K.* (2007)
β-catenin signaling promotes proliferation of progenitor cells in the adult mouse subventricular zone.
Stem Cells 25, 2827-2836.
4. Yamashita, T., Ninomiya, M., Hernandez Acosta, P., Garcia-Verdugo, J. M., Sunabori, T., Sakaguchi, M., Adachi, K., Kojima, T., Hirota, Y., Kawase, T., Araki, N., Abe, K., Okano, H., and Sawamoto, K.* (2006).
Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum.
J Neurosci 26, 6627-6636.
5. Kaneko, N., Okano, H.*, and Sawamoto, K.* (2006).
Role of the cholinergic system in regulating survival of newborn neurons in the adult mouse dentate gyrus and olfactory bulb.
Genes Cells 11, 1145-1159.
6. Ninomiya, M., Yamashita, T., Araki, N., Okano, H., and Sawamoto, K.* (2006).
Enhanced neurogenesis in the ischemic striatum following EGF-induced expansion of transit-amplifying cells in the subventricular zone.
Neurosci Lett 403, 63-67.
7. Sawamoto, K.*, Wichterle, H., Gonzalez-Perez, O., Cholfin, J. A., Yamada, M., Spassky, N., Murcia, N. S., Garcia-Verdugo, J. M., Marin, O., Rubenstein, J. L., Tessier-Lavigne, M., Okano, H., and Alvarez-Buylla, A.* (2006).
New neurons follow the flow of cerebrospinal fluid in the adult brain.
Science 311, 629-632.
8. Sakaguchi, M., Shingo, T., Shimazaki, T., Okano, H. J., Shiwa, M., Ishibashi, S., Oguro, H., Ninomiya, M., Kadoya, T., Horie, H., Shibuya, A., Mizusawa, H., Poirier, F., Nakauchi, H., Sawamoto, K. and Okano, H. (2006).
A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells.
Proc Natl Acad Sci U S A 103, 7112-7117.
9. Yamashima, T., Popivanova, B. K., Guo, J., Kotani, S., Wakayama, T., Iseki, S., Sawamoto, K., Okano, H., Fujii, C., Mukaida, N., and Tonchev, A. B. (2006).
Implication of “Down syndrome cell adhesion molecule” in the hippocampal neurogenesis of ischemic monkeys.
Hippocampus 16, 924-935.
10. Toriya, M., Tokunaga, A., Sawamoto, K., Nakao, K., and Okano, H. (2006).
Distinct functions of human numb isoforms revealed by misexpression in the neural stem cell lineage in the Drosophila larval brain.
Dev Neurosci 28, 142-155.
11. Tonchev, A. B., Yamashima, T., Sawamoto, K., and Okano, H. (2006).
Transcription factor protein expression patterns by neural or neuronal progenitor cells of adult monkey subventricular zone.
Neuroscience 139, 1355-1367.
12. Miyagi, S., Nishimoto, M., Saito, T., Ninomiya, M., Sawamoto, K., Okano, H., Muramatsu, M., Oguro, H., Iwama, A., and Okuda, A. (2006).
The Sox2 regulatory region 2 functions as a neural stem cell-specific enhancer in the telencephalon.
J Biol Chem 281, 13374-13381.
13. Hirota, Y., Sawamoto, K., Takahashi, K., Ueda, R., and Okano, H. (2005).
The transmembrane protein, Tincar, is involved in the development of the compound eye in Drosophila melanogaster.
Dev Genes Evol 215, 90-96.
14. Kanuka, H., Hiratou, T., Igaki, T., Kanda, H., Kuranaga, E., Sawamoto, K., Aigaki, T., Okano, H., and Miura, M. (2005).
Gain-of-function screen identifies a role of the Sec61alpha translocon in Drosophila postmitotic neurotoxicity.
Biochim Biophys Acta 1726, 225-237.
15. Sakaguchi, M., Sawamoto, K., Shimazaki, T., Kitamura, T., Shibuya, A., and Okano, H. (2005).
A method for gene transfer, single isolation, and in vitro assay for neural stem cells. Inflamation and Regeneration 25, 50-54.
16. Suzuki, S., Yamashita, T., Tanaka, K., Hattori, H., Sawamoto, K., Okano, H., and Suzuki, N. (2005).
Activation of cytokine signaling through leukemia inhibitory factor receptor (LIFR)/gp130 attenuates ischemic brain injury in rats.
J Cereb Blood Flow Metab 25, 685-693.
17. Tonchev, A. B., Yamashima, T., Sawamoto, K., and Okano, H. (2005).
Enhanced proliferation of progenitor cells in the subventricular zone and limited neuronal production in the striatum and neocortex of adult macaque monkeys after global cerebral ischemia.
J Neurosci Res 81, 776-788.
18. Yamashita, T., Sawamoto, K., Suzuki, S., Suzuki, N., Adachi, K., Kawase, T., Mihara, M., Ohsugi, Y., Abe, K., and Okano, H. (2005).
Blockade of interleukin-6 signaling aggravates ischemic cerebral damage in mice: possible involvement of Stat3 activation in the protection of neurons.
J Neurochem 94, 459-468.
19. Tokunaga, A., Kohyama, J., Yoshida, T., Nakao, K., Sawamoto, K., and Okano, H. (2004). Mapping spatio-temporal activation of Notch signaling during neurogenesis and gliogenesis in the developing mouse brain.
J Neurochem 90, 142-154.
20. Unezaki, S., Nishizawa, M., Okuda-Ashitaka, E., Masu, Y., Mukai, M., Kobayashi, S., Sawamoto, K., Okano, H., and Ito, S. (2004).
Characterization of the isoforms of MOVO zinc finger protein, a mouse homologue of Drosophila Ovo, as transcription factors.
Gene 336, 47-58.
21. Yamashima, T., Tonchev, A. B., Vachkov, I. H., Popivanova, B. K., Seki, T., Sawamoto, K., and Okano, H. (2004).
Vascular adventitia generates neuronal progenitors in the monkey hippocampus after ischemia.
Hippocampus 14, 861-875.
22. Yoshizaki, T., Inaji, M., Kouike, H., Shimazaki, T., Sawamoto, K., Ando, K., Date, I., Kobayashi, K., Suhara, T., Uchiyama, Y., and Okano, H. (2004).
Isolation and transplantation of dopaminergic neurons generated from mouse embryonic stem cells.
Neurosci Lett 363, 33-37.
23. Hirota, Y., Sawamoto, K., and Okano, H. (2002).
tincar encodes a novel transmembrane protein expressed in the Tinman-expressing cardioblasts of Drosophila.
Mech Dev 119 Suppl 1, S279-283.
24. Kuranaga, E., Kanuka, H., Igaki, T., Sawamoto, K., Ichijo, H., Okano, H., and Miura, M. (2002).
Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila.
Nat Cell Biol 4, 705-710.
25. Ogawa, Y., Sawamoto, K., Miyata, T., Miyao, S., Watanabe, M., Nakamura, M., Bregman, B. S., Koike, M., Uchiyama, Y., Toyama, Y., and Okano, H. (2002).
Transplantation of in vitro-expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats.
J Neurosci Res 69, 925-933.
26. Uchida, M., Hanai, S., Uematsu, N., Sawamoto, K., Okano, H., Miwa, M., and Uchida, K. (2002).
Overexpression of poly(ADP-ribose) polymerase disrupts organization of cytoskeletal F-actin and tissue polarity in Drosophila.
J Biol Chem 277, 6696-6702.
27. Kawaguchi, A., Miyata, T., Sawamoto, K., Takashita, N., Murayama, A., Akamatsu, W., Ogawa, M., Okabe, M., Tano, Y., Goldman, S. A., and Okano, H. (2001).
Nestin-EGFP transgenic mice: visualization of the self-renewal and multipotency of CNS stem cells.
Mol Cell Neurosci 17, 259-273.
28. Sawamoto, K., Yamamoto, A., Kawaguchi, A., Yamaguchi, M., Mori, K., Goldman, S. A., and Okano, H. (2001).
Direct isolation of committed neuronal progenitor cells from transgenic mice coexpressing spectrally distinct fluorescent proteins regulated by stage-specific neural promoters.
J Neurosci Res 65, 220-227.
29. Sawamoto, K., Nakao, N., Kakishita, K., Ogawa, Y., Toyama, Y., Yamamoto, A., Yamaguchi, M., Mori, K., Goldman, S. A., Itakura, T., and Okano, H. (2001).
Generation of dopaminergic neurons in the adult brain from mesencephalic precursor cells labeled with a nestin-GFP transgene.
J Neurosci 21, 3895-3903.
30. Sawamoto, K., Nakao, N., Kobayashi, K., Matsushita, N., Takahashi, H., Kakishita, K., Yamamoto, A., Yoshizaki, T., Terashima, T., Murakami, F., Itakura, T. and Okano, H. (2001).
Visualization, direct isolation, and transplantation of midbrain dopaminergic neurons.
Proc Natl Acad Sci U S A 98, 6423-6428.
31. Uchida, M., Hanai, S., Uematsu, N., Sawamoto, K., Okano, H., Miwa, M., and Uchida, K. (2001).
Genetic and functional analysis of PARP, a DNA strand break-binding enzyme.
Mutat Res 477, 89-96.
32. Igaki, T., Kanuka, H., Inohara, N., Sawamoto, K., Nunez, G., Okano, H., and Miura, M. (2000).
Drob-1, a Drosophila member of the Bcl-2/CED-9 family that promotes cell death.
Proc Natl Acad Sci U S A 97, 662-667.
33. Jin, M. H., Sawamoto, K., Ito, M., and Okano, H. (2000).
The interaction between the Drosophila secreted protein argos and the epidermal growth factor receptor inhibits dimerization of the receptor and binding of secreted spitz to the receptor.
Mol Cell Biol 20, 2098-2107.
34. Kaneko, Y., Sakakibara, S., Imai, T., Suzuki, A., Nakamura, Y., Sawamoto, K., Ogawa, Y., Toyama, Y., Miyata, T., and Okano, H. (2000).
Musashi1: an evolutionally conserved marker for CNS progenitor cells including neural stem cells.
Dev Neurosci 22, 139-153.
35. Tabuchi, K., Sawamoto, K., Suzuki, E., Ozaki, K., Sone, M., Hama, C., Tanifuji-Morimoto, T., Yuasa, Y., Yoshihara, Y., Nose, A., and Okano, H. (2000).
GAL4/UAS-WGA system as a powerful tool for tracing Drosophila transsynaptic neural pathways.
J Neurosci Res 59, 94-99.
36. Taguchi, A., Sawamoto, K., and Okano, H. (2000).
Mutations modulating the Argos-regulated signaling pathway in Drosophila eye development.
Genetics 154, 1639-1648.
37. Fujimoto, J., Sawamoto, K., Okabe, M., Takagi, Y., Tezuka, T., Yoshikawa, S., Ryo, H., Okano, H., and Yamamoto, T. (1999).
Cloning and characterization of Dfak56, a homolog of focal adhesion kinase, in Drosophila melanogaster.
J Biol Chem 274, 29196-29201.
38. Hirota, Y., Okabe, M., Imai, T., Kurusu, M., Yamamoto, A., Miyao, S., Nakamura, M., Sawamoto, K., and Okano, H. (1999).
Musashi and seven in absentia downregulate Tramtrack through distinct mechanisms in Drosophila eye development.
Mech Dev 87, 93-101. (Cover picture)
39. Kanuka, H., Sawamoto, K., Inohara, N., Matsuno, K., Okano, H., and Miura, M. (1999).
Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activator.
Mol Cell 4, 757-769.
40. Kanuka, H., Hisahara, S., Sawamoto, K., Shoji, S., Okano, H., and Miura, M. (1999).
Proapoptotic activity of Caenorhabditis elegans CED-4 protein in Drosophila: implicated mechanisms for caspase activation.
Proc Natl Acad Sci U S A 96, 145-150.
41. Sawamoto, K., Winge, P., Koyama, S., Hirota, Y., Yamada, C., Miyao, S., Yoshikawa, S., Jin, M. H., Kikuchi, A., and Okano, H. (1999).
The Drosophila Ral GTPase regulates developmental cell shape changes through the Jun NH(2)-terminal kinase pathway.
J Cell Biol 146, 361-372. (Cover picture)
42. Sawamoto, K., Yamada, C., Kishida, S., Hirota, Y., Taguchi, A., Kikuchi, A., and Okano, H. (1999).
Ectopic expression of constitutively activated Ral GTPase inhibits cell shape changes during Drosophila eye development.
Oncogene 18, 1967-1974.
43. Yoshihara, Y., Mizuno, T., Nakahira, M., Kawasaki, M., Watanabe, Y., Kagamiyama, H., Jishage, K., Ueda, O., Suzuki, H., Tabuchi, K., Sawamoto, K., Okano, H., Noda, T. and Mori, K. (1999).
A genetic approach to visualization of multisynaptic neural pathways using plant lectin transgene.
Neuron 22, 33-41.
44. Saito, T., Sawamoto, K., Okano, H., Anderson, D. J., and Mikoshiba, K. (1998). Mammalian BarH homologue is a potential regulator of neural bHLH genes.
Dev Biol 199, 216-225.
45. Sawamoto, K., Taguchi, A., Hirota, Y., Yamada, C., Jin, M. H., and Okano, H. (1998).
Argos induces programmed cell death in the developing Drosophila eye by inhibition of the Ras pathway.
Cell Death Differ 5, 262-270.
46. Tabuchi, K., Yoshikawa, S., Yuasa, Y., Sawamoto, K., and Okano, H. (1998).
A novel Drosophila paired-like homeobox gene related to Caenorhabditis elegans unc-4 is expressed in subsets of postmitotic neurons and epidermal cells.
Neurosci Lett 257, 49-52.
47. Sawamoto, K.*, and Takahashi, N. (1997).
Modulation of hepatocyte function by changing the cell shape in primary culture.
In Vitro Cell Dev Biol Anim 33, 569-574.
48. Okabe, M., Sawamoto, K., and Okano, H. (1996).
The function of the Drosophila argos gene product in the development of embryonic chordotonal organs.
Dev Biol 175, 37-49.
49. Sawamoto, K., Okabe, M., Tanimura, T., Mikoshiba, K., Nishida, Y., and Okano, H. (1996).
The Drosophila secreted protein Argos regulates signal transduction in the Ras/MAPK pathway.
Dev Biol 178, 13-22.
50. Sawamoto, K., Okabe, M., Tanimura, T., Hayashi, S., Mikoshiba, K., and Okano, H. (1996).
argos Is required for projection of photoreceptor axons during optic lobe development in Drosophila.
Dev Dyn 205, 162-171. (Cover picture)
51. Sawamoto, K., and Takahashi, N. (1995).
Changes in the organelle arrangement in primary cultured hepatocytes following the formation of cytoskeleton.
Int J Tissue React 17, 205-210.
52. Okano, H., Yoshikawa, S., Suzuki, A., Ueno, N., Kaizu, M., Okabe, M., Takahashi, T., Matsumoto, M., Sawamoto, K., and Mikoshiba, K. (1994).
Cloning of a Drosophila melanogaster homologue of the mouse type-I bone morphogenetic proteins-2/-4 receptor: a potential decapentaplegic receptor.
Gene 148, 203-209.
53. Sawamoto, K., Okano, H., Kobayakawa, Y., Hayashi, S., Mikoshiba, K., and Tanimura, T. (1994).
The function of argos in regulating cell fate decisions during Drosophila eye and wing vein development.
Dev Biol 164, 267-276.
54. Okano, H., Hayashi, S., Tanimura, T., Sawamoto, K., Yoshikawa, S., Watanabe, J., Iwasaki, M., Hirose, S., Mikoshiba, K., and Montell, C. (1992).
Regulation of Drosophila neural development by a putative secreted protein.
Differentiation 52, 1-11. (Cover picture)